Obviously, I am interested with metastatic thyroid cancer & its complexities/complications. Readings that suggest complete thyroidectomy - as was done in the case of which I am concerned - specifically employed T4 to suppress TSH. I am unsure of the role of tetrac, but I have read it is employed in metastatic cases with "inhibiting angiogenesis and disrupting cancer cell proliferation through non-genomic pathways." While I understand that with thyroidectomy, it necessitates synthetic T4 supplementation, is this also true of tetrac? Below are the two studies I read to reach the (perhaps dubious?) conclusion that I did.
Davis, PJ, Davis, FB, Mousa, SA, Luidens, MK, Lin, HY. Membrane receptor for thyroid hormone: physiologic and pharmacologic implications. Annu Rev Pharmacol Toxicol. 2011:51:99-115. https://doi.org/10.1146/annurev-pharmtox-010510-100512.
Glinskii, GV, Huxley, VH, Glinsky, GV, Pienta, KJ, Raz, A, Glinsky, VV. Mechanical entrapment is insufficient and intercellular
Given I am not a medical professional, I don't know what the standard of care is right now after thyroidectomy, but I suspect it does not yet include Tetrac. It usually takes decades before scientific findings make it into the biomedical standard of care. In the future, I envision that exogenous Tetrac could be supplied together with T4 in appropriate amounts, or the body's own (yet unknown) conversion mechanism could be stimulated, once the corresponding deaminase is identified.
Well, most studies I read said "speculative" and "experimental," but likewise were >10 years old. Therefore, I may reasonably conclude there are no "dumb" questions, only "yet to be answered" questions. I could not find a standard of care in anything I read, so don't be concerned. I'll check back with you in, say, 5-years!
Obviously, I am interested with metastatic thyroid cancer & its complexities/complications. Readings that suggest complete thyroidectomy - as was done in the case of which I am concerned - specifically employed T4 to suppress TSH. I am unsure of the role of tetrac, but I have read it is employed in metastatic cases with "inhibiting angiogenesis and disrupting cancer cell proliferation through non-genomic pathways." While I understand that with thyroidectomy, it necessitates synthetic T4 supplementation, is this also true of tetrac? Below are the two studies I read to reach the (perhaps dubious?) conclusion that I did.
Davis, PJ, Davis, FB, Mousa, SA, Luidens, MK, Lin, HY. Membrane receptor for thyroid hormone: physiologic and pharmacologic implications. Annu Rev Pharmacol Toxicol. 2011:51:99-115. https://doi.org/10.1146/annurev-pharmtox-010510-100512.
Glinskii, GV, Huxley, VH, Glinsky, GV, Pienta, KJ, Raz, A, Glinsky, VV. Mechanical entrapment is insufficient and intercellular
Given I am not a medical professional, I don't know what the standard of care is right now after thyroidectomy, but I suspect it does not yet include Tetrac. It usually takes decades before scientific findings make it into the biomedical standard of care. In the future, I envision that exogenous Tetrac could be supplied together with T4 in appropriate amounts, or the body's own (yet unknown) conversion mechanism could be stimulated, once the corresponding deaminase is identified.
Well, most studies I read said "speculative" and "experimental," but likewise were >10 years old. Therefore, I may reasonably conclude there are no "dumb" questions, only "yet to be answered" questions. I could not find a standard of care in anything I read, so don't be concerned. I'll check back with you in, say, 5-years!