Perhaps one of the most puzzling aspects of COVID-19 is its dichotomy between asymptomatic/mild cases and an unusual (for a viral illness) hyper-inflammatory symptomatology of severe cases. Here, I would like to draw the connections between a triad of players, which may explain the puzzle: the Spike protein, mast cells, and vitamin D.
Spike protein and mast cell activation
Perhaps one of the most puzzling aspects of COVID-19 is its dichotomy between asymptomatic/mild cases and an unusual (for a viral illness) hyper-inflammatory symptomatology of severe cases. Here, I would like to draw the connections between a triad of players, which may explain the puzzle: the Spike protein, mast cells, and vitamin D.
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